Two Lumps - A comic about two lumps.  Er, cats.  Updated three times a week, it's the most accurate depiction of feline life I've seen.  And I watch Animal Planet.

Te-land - Had to include a fan-fic site, and this is one.  Thankfully, it's mostly porn.

PVP Online - A comic strip by a geek, for geeks.  There's a troll involved.  'nuff said.  (Note: You want a Skull plushie.  You need a Skull plushie...)

Despair.com - They look like Successories, but with a slightly more pessimistic (and realistic) worldview.  The perfect cubicle accessories for a Dilbert world.  (Note: spring for the Executive Edition Pessimist's Mug.  Worth it for the etching.)

ThinkGeek - Stuff for smart people and those who need caffeine from more sources than just liquid ingestion.

Cuteoverload - Some days you need a dose of fluffy bunnies and puppies doing aggressively adorable things.  This is the place to get it.

Global Scent - Essential oils, perfumes, incense, and body care products.  I'm a huge fan of their Moon scent.

Bishonen Works - PL Nunn's art site of English-language doujinshi, art, stickers, and more.  WARNING: most of the images are NOT work-safe (but that's the fun part).